杜晶，研究员，复旦大学药理学专业博士生导师，现任上海市生物医药技术研究院营养与妇幼健康研究室主任，课题组PI，妇幼健康研究会安全避孕专业委员会、上海市医师协会生殖医学医师分会第二届委员会、上海市抗癌协会遗传性消化道肿瘤专业委员会、中华医学会计划生育学分会生物信息学组委员及中华生殖与避孕杂志通讯编委等。曾在新加坡Duke-NUS医学研究生院进行了两年博士后工作，并曾在澳大利亚阿德莱德大学医学院生殖遗传学研究室进行了1年的访问学者研究。主要从事生殖遗传学、表观遗传学以及基因突变与生殖疾病关联和功能等方面的科研工作。研究内容包括卵巢早衰的发病机制，生殖疾病药物基因组学以及复发性流产的遗传及表观遗传易感因素等，对于流产等疾病分子机理研究取得了初步成果，揭示了某些功能基因多态性、DNA甲基化及非编码RNA等可能发挥的潜在作用，在复发性流产等女性生殖系统相关疾病的遗传学及表观遗传学研究方面形成了一定的研究特色。
       近5年先后主持国家自然基金面上项目3项，曾主持及参与国家十三五科技支撑计划项目、国家973项目、国家及上海市自然科学基金等；发表论文100余篇（SCI论文80多篇），相关文章发表在Fertility and Sterility，Clinical Epigenetics, Journal of Clinical Endocrinology & Metabolism等国际权威杂志上，同时申请了多项发明专利，于2014-2017 年连续入选医学领域中国高被引用论文学者榜单，并于2015、2021年分获妇幼健康科学技术奖自然科学奖二等奖。

近年主要论文：

1.Chen F, Li M, Fei X, Chen X, Zhang Z, Zhu W, Shen Y, Mao Y, Liu J, Xu J, Du J（通讯作者). Predictive plasma biomarker for gestational diabetes: A case-control study in China, J Proteomics. 2022 Nov 11;271:104769. doi: 10.1016/j.jprot.2022.104769.

2.Chen FJ, Fei XP, Zhu WQ, Zhang ZF, Shen YP, Mao YY, Zhu QX, Xu JH, Zhou WJ, Li M, Du J（通讯作者). Placental DNA Methylation changes in the gestational diabetes mellitus. Epigenetics,2022 Aug 21:1-13. doi: 10.1080/15592294.2022.2110193.

3.Zhu WQ, Gu Y, Li M, Zhang ZF, Liu JW, Shen YP, Chen FJ, Xin YW, Xia LJ, He L,Du J（通讯作者). Integrated single-cell RNA sequencing and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion, Clinical Epigenetics, 2022 Aug 23;14(1):105. doi: 10.1186/s13148-022-01327-2.

4.Xia LJ, Du J（通讯作者). Mechanical stress-induced Hippo signalling in respect to primordial follicle development and PCOS pathogenesis. Reprod Dev Med, 2022,06(2) : 121-128. doi: 10.1097 /RD9.0000000000000009 （封面文章）

5.Liu JW, Zhang ZF, Zhu WQ, Shen YP, Gu Y, Zhang X, He L, Du J（通讯作者). CircFBXW4 regulates human trophoblast cell proliferation and invasion via targeting miR-324-3p/TJP1 axis in recurrent spontaneous abortion. Placenta, 2022 May 28;126:1-11.doi: 10.1016/j.placenta.2022.05.016. Online ahead of print.

6.Liu JW, Gu Y, Zhang ZF, Zhu WQ, Shen YP,Xu JH, Du J（通讯作者). Expression profiles of circular RNA in human placental villus and decidua and prediction of drugs for recurrent spontaneous abortion , Am J Reprod Immunol, 2022 May 18;e13578. doi: 10.1111/aji.13578. Online ahead of print.

7.Shen YP, Xiong Y, Zhang ZP, Zhang BH, Li AH, Zhang ZF, Ding J, Du J（通讯作者), Che Y. Whole Exome Sequencing Identifies genetic variants in Chinese Han pregnant women with Venous thromboembolism-a case control study. Thromb Res. 2022 Mar;211:49-55. doi: 10.1016/j.thromres.2022.01.015. Epub 2022 Jan 19.

8.Zhu WQ, Zhang JX, Yuan XL, Liu XL, Zhang ZF, Mao YY, Feng Y, Yue AL, Sun JJ, Wen C, Xu JH, Shen YP, Che Y, Du J（通讯作者). Whole-exome sequencing reveals novel candidate SNVs for preventing adverse effects of Levonorgestrel implantation . Pharmacogenomics, 2021 Nov 16. doi: 10.2217/pgs-2021-0105.

9.Shen YP，Xu LF, Zhu WQ, Zhang ZF, Liu JW, Jiang LF, Liu XL, Mao YY, Xu JH, Yan XQ, Sun JJ, Liu F, Xiong XM, Chen XJ, Che Y, Du J（通讯作者). Associations of MCM8 rs3761873 and rs16991617 Variants with Abnormal Uterine Bleeding Induced by Copper Intrauterine Device. J Obstet Gynaecol Res . 2021 Dec 10. doi: 10.1111/jog.15101.

10.Song D, Hong L, Zhang ZF, Xu JH, Zhang HQ, Huang XL, Du J（通讯作者). The FSHR G-29A variant is not associated with the ovarian response to exogenous FSH stimulation. Am J Reprod Immunol, 2021 Sep 23:e13500. doi: 10.1111/aji.13500.

11.Song XX, Wang ZL, Zhang ZF, Miao MH, Liu JW, Luan M, Du J（通讯作者), Liang H, Yuan W. Differential methylation of genes in the human placenta associated with bisphenol A exposure. Environ Res, 2021 Sep 200:111389. doi:10.1016/j.envres.2021.111389.

12.Liu JW, Jiang LF, Liu XL, Xu LF, Xu JH, Zhu WQ, Shen YP, Zhang ZF, Mao YY, Yan XQ, Sun JJ, Liu F, Xiong XM, Chen XJ, Che Y, Du J（通讯作者). TMT-based quantitative proteomic profiling of the serum of patients with abnormal uterine bleeding associated with copper intrauterine device. Int J Gynaecol Obstet. 2021 Jul;154(1):169-178. doi: 10.1002/ijgo.13562. Epub 2021 Jan 13.

13.Zhu WQ, Shen YP, Liu JW, Fei XP, Zhang ZF, Li M, Chen XH, Xu JH, Zhu QX, Zhou WJ, Zhang MH, Liu SQ, Du J（通讯作者). Epigenetic alternations of microRNAs and DNA methylation contribute to gestational diabetes mellitus.J Cell Mol Med. 2020 Dec;24(23):13899-13912.

14.Zhao L; Xue SG; Wu L;Sun XX; Yao ZY; Shi JZ;Chen BB;Sun LH; Xu Y; Yan Z; Li B; Fu J; Zhang ZH; Mu J;Zhou Z; Wang WJ; Du J; Liu S; Dong J; Wang WJ; Jin L; He L; Liang XZ; Kuang YP; Sang Q*; Wang L*. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell. 2020 Jul 14. doi: 10.1007/s13238-020-00756-0. Online ahead of print.

15.Pi L#, Zhang Z#, Gu Y, Wang X, Wang J, Xu J, Liu J, Zhang X, Du J（通讯作者). DNA methylation profiling in recurrent miscarriage. PeerJ. 2020 Jan 7;8:e8196. doi: 10.7717/peerj.8196. eCollection 2020.

16.Zhu WQ#, Du J# （第一作者）, Chen Q, Zhang ZF, Wu B, Xu JH, Li TQ, Bi Y, Shi HJ*,Li RS*. Association of UHRF1 gene polymorphisms with oligospermia in Chinese males . J Assist Reprod Genet. 2019 Dec;36(12):2563-2573. doi: 10.1007/s10815-019-01614-7.

17.Zhang W, Li Min, Sun F, Xu XT, Zhang ZF, Liu J, Shun XW, Zhang AP, Shen Y, Xu JH, Miao MH, Wu B, Yuan Y, Huang XL,Shi HJ, Du J（通讯作者). Association of Sperm Methylation at LINE-1, Four Candidate Genes, and Nicotine/Alcohol Exposure With the Risk of Infertility. Front Genet. 2019 Oct 18;10:1001. doi: 10.3389/fgene.2019.01001. eCollection 2019.

18.Liu J, Zhang Z, Xu J, Song X, Yuan W, Miao M, Liang H, Du J（通讯作者). Genome-wide DNA methylation changes in placenta tissues associated with small for gestational age newborns; cohort study in the Chinese population. Epigenomics. 2019 Sep;11(12):1399-1412. doi: 10.2217/epi-2019-0004. Epub 2019 Oct 9.

19.Song D, Huang X, Hong L, Yu J, Zhang Z, Zhang H, Sun Z, Du J（通讯作者). Sequence variants in FSHR and CYP19A1 genes and the ovarian response to controlled ovarian stimulation. Fertil Steril. 2019 Oct;112(4):749-757.e2.

20.Sang Q, Zhang Z, Shi J, Sun X, Li B, Yan Z, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y, Wang L. A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med. 2019 Mar 27;11(485). pii: eaav8731. doi: 10.1126/scitranslmed.aav8731.