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专家介绍(科研)
张 婷
zhang ting
发布时间:2019-05-08

 

       张婷,上海市计划生育科学研究所副研究员,2003年博士毕业于中科院上海药物研究所。主要从事药物对女性生殖系统毒性机制研究,女性生殖系统疾病新药开发及不孕不育相关细胞和动物模型建立等方面的科研工作。博士毕业后在外资医药研发公司从事新药药效和安全性评价的科研工作,2008年曾在美国密西根大学做短期访问学者。2011年加入上海市计划生育科学研究所,在药物发展研究室主要从事药物对女性生殖系统毒性的机制研究,同时还从事女性生殖系统肿瘤和不孕不育治疗方面的新药开发及相关细胞动物模型的建立。研究内容包括药物引起的卵巢毒性如卵巢早衰、子宫内膜毒性和子代发育毒性;治疗卵巢早衰的新药筛选和开发;纳米脂质体包载的17β-HSD1 siRNA抗雌激素依赖性乳腺癌的临床前研究;基于肿瘤表观遗传学修饰的靶向卵巢癌先导化合物的发现和机制研究;女性不孕不育疾病细胞和动物模型的建立。研究发现化疗药物引起的卵巢早衰与卵泡颗粒细胞的凋亡,活性氧族的升高,线粒体膜损伤有较大的关系,并且受Bcl-2,Bax,p53等基因的调控,基于此机制进行治疗药物的开发;17β-HSD1 siRNA药物对激素依赖性乳腺癌具有较好的治疗作用。迄今为止共发表论文28篇,第一作者和通讯作者的论文14篇(其中SCI论文篇6篇),其它作者14篇(其中SCI论文11篇),相关文章发表在Regulatory Toxicology and Pharmacology、Biomedical Chromatography、中国药理学报、中国药理学和毒理学杂志等国内外药物研究权威杂志上,同时担任Human & Experimental Toxicology杂志的审稿人。
       现主持上海市科技创新行动计划生物医药专项项目等课题。曾主持1项上海市自然科学基金面上项目、1项科技创新行动计划实验动物专项、1项上海市计划生育科学研究所青年科技创新基金项目;参与了2项国家十二五重大专项(为子课题负责人)项目;申请发明专利1项。
       近5年研究论文:
       1. Ting Zhang, Ying Chen, Yang Yang, Zhonghui Wang, Qi Pan, Sichong Xu, Zuyue Sun. The potentiality of two-dimensional preantral follicle culture as an in vitro model in predicting premature ovarian failure. Exp Toxicol Pathol. 2017, 69(7):477-484
       2. Ting Zhang, WanhongHe, Linglin Feng, Haoguang Huang. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regul Toxicol Pharmacol. 2017, 86, 1-10
       3. Ting Zhang, Dawei Yan, Yang Yang, Aicui Ma, Lei Li, Zhonghui Wang, Qi Pan, Zuyue Sun. The comparison of animal models for premature ovarian failure established by several different source of inducers. Regul Toxicol Pharmacol. 2016, 81, 223-232
       4. Ting Zhang, Wan-hong He, Ling-lin Feng. Ovarian toxicity induced by chemotherapy:research progress. Chin J Pharmacol Toxicol. 2016, 30(8):879-885
       5. Xiang Meng, Ting Zhang, Ying Li, Qi Pan, Juan Jiang, Yongwei Luo, Liming Chong, Yang Yang, Sichong Xu, Li Zhou and Zuyue Sun. Development and application of an analytical method for curdione quantification in pregnant sprague–dawley rats by LC-MS/MS. Biomedical Chromatography, 2015, 29(10):1499-1505
       6. Xiang Meng, Ting Zhang, Ying Li, Qi Pan, Juan Jiang, Yongwei Luo, Liming Chong, Yang Yang, Sichong Xu, Li Zhou, Zuyue Sun. The toxicokinetic profile of curdione in pregnant SD rats and its transference in a placental barrier system detected by LC–MS/MS. Regul. Toxicol. Pharm. 2015, 17 (2):158-163
       7. Ting Zhang, Lei Li, Zhonghui Wang, Jianyan Yan, Qi Pan, Xiangyun Liu, Zuyue Sun. Effect of doxorubicin on the development of cultured preantral follicles in mice. Carcinogenesis, Teratogenesis and Mutagenesis.2013, 25(5):360-364
       8. Ting Zhang, Yi Cheng, Yong Wang, Zuyue Sun. The female reproductive toxicity of exogenous chemicals:research progress. Carcinogenesis, Teratogenesis and Mutagenesis. 2013, 25(2):155-158
       9. Hong Sun, Ting Zhang, Bo Gui, Liwen Song, Lei Li, Qi Pan, Rongfu Yang, Yue Shao, Xiangyun Liu,Zuyue Sun. Establishment of prostate cancer in cynomolgus macaque animal model by orthotropic inoculation of PC-3 cancer cells in situ. Eur.J.Oncol, 2012, 17(4):189-203
       10. Hong Sun,Ting Zhang, Xin Su, Xiang Meng, Zu-yue Sun. A Newly-developed RP-HPLC Method for the Analysis of Epristeride in Rat Serum and its Validation. Lat. Am. J. Pharm. 2012, 31 (8): 1132-1137
       申请专利一项:1、《一种治疗风湿性关节炎的药物》申请号:200310124512.0,专利号ZL 200310124512.0
       电话:021-34617493E-mail: zhangting@sippr.org.cn or fuzzyting@163.com

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