Prof. Du Jing, Principal Investigator (PI) in Shanghai Institute of Planned Parenthood Research (SIPPR), and Supervisor for Ph.D. Candidates in School of Pharmacy of Fudan University.. She served as a member of bioinformatics group of family planning branch of Chinese Medical Association, a member of reproductive medicine branch of Shanghai Medical Association, a communication editorial board member of Chinese Journal of reproduction and contraception, etc,she mainly engaged in biochemistry and molecular biology, pharmacogenomics, reproductive genetics, epigenetics, gene mutation and disease related and functional research. She has conducted two-year postdoctoral research in Duke-NUS Graduate School of medicine, which is jointly run by National University of Singapore and Duke University of the United States. From February 2013 to February 2014, she went to the reproductive genetics research office of Adelaide University School of medicine in Australia to conduct a one-year visiting scholar research.
In Shanghai Family Planning Institute, she is mainly engaged in the research of reproductive genetics, epigenetics and the relationship and function between gene mutation and reproductive diseases. The research contents include the pathogenesis of premature ovarian failure and polycystic ovarian syndrome, pharmacogenomics of reproductive diseases, genetic and epigenetic susceptibility factors of recurrent abortion, etc.
In the past five years, she has presided over 2 general projects of NSFC, 1 scientific and technological activity project for overseas students, 1 Key Laboratory Project of family planning medicine of national health commission, 1 key research and development project of national 13th five year plan, 1 general project of NSFC, 1 leading talent project of Shanghai, etc., presided over and participated in the national 13th five year plan of science and technology support Objectives, national 973 program, etc.; 73 academic papers (50 SCI papers) were published, and relevant articles were published in the international authoritative magazines such as fertility and sterlity, Journal of Clinical Endocrinology & metabolism, genes and nutrition, etc., and won the second prize of Natural Science Award of women and children's Health Science and Technology Award in 2015.
Major papers in recent years:
1. Pi L#, Zhang Z#, Gu Y, Wang X, Wang J, Xu J, Liu J, Zhang X*, Du J(通讯作者)*. DNA methylation profiling in recurrent miscarriage. PeerJ.2020 Jan 7;8:e8196. doi: 10.7717/peerj.8196. eCollection 2020.
2. Zhu WQ#, Du J#, Chen Q, Zhang ZF, Wu B, Xu JH, Li TQ, Bi Y, Shi HJ*,Li RS*. Association of UHRF1 gene polymorphisms with oligospermia in Chinese males. J Assist Reprod Genet, 2019 Dec;36(12):2563-2573. doi: 10.1007/s10815-019-01614-7.
3. Wang W, Dong J, Chen B, Du J, Kuang Y, Sun X, Fu J, Li B, Mu J, Zhang Z, Zhou Z, Lin Z, Wu L, Yan Z, Mao X, Li Q, He L, Wang L, Sang Q. Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest. J Med Genet. 2020 Mar;57(3):187-194. doi: 10.1136/jmedgenet-2019-106379. Epub 2019 Nov 8.
4. Zhang W, Li Min, Sun F, Xu XT, Zhang ZF, Liu J, Shun XW, Zhang AP, Shen Y, Xu JH, Miao MH, Wu B, Yuan Y, Huang XL,Shi HJ, Du J(通讯作者). Association of Sperm Methylation at LINE-1, Four Candidate Genes, and Nicotine/Alcohol Exposure With the Risk of Infertility.Front Genet. 2019 Oct 18;10:1001. doi: 10.3389/fgene.2019.01001. eCollection 2019.
5. Liu J, Zhang Z, Xu J, Song X, Yuan W, Miao M, Liang H,Du J(通讯作者). Genome-wide DNA methylation profile of placenta tissues identifies differentially methylated CpG site associated with Small for Gestational Age. Epigenomics. 2019 Sep;11(12):1399-1412. doi: 10.2217 / epi – 2019-0004. Epub 2019 Oct 9.
6. Song D, Huang X, Hong L, Yu J, Zhang Z, Zhang H, Sun Z, Du J(通讯作者). Sequence variants in FSHR and CYP19A1 genes and the ovarian response to controlled ovarian stimulation. Fertil Steril. 2019 Oct;112(4):749-757.e2. doi: 10.1016/j.fertnstert.2019.05.017. Epub 2019 Jul 29.
7. Sang Q#*, Zhang Z#, Shi J#, Sun X#, Li B#, Yan Z#, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y*, Wang L*. A pannexin 1 channelopathy causes human oocyte death.Sci Transl Med. 2019 Mar 27;11(485). pii: eaav8731. doi: 10.1126/scitranslmed.aav8731.
8. Ren D#, Xu JH#, Bi Y, Zhang Z, Zhang R, Li Y, Hu J, Guo Z, Niu W, Yang F, Li W, Xu Y, He L, Yu T, Wu J*, Li X*, Du J(通讯作者)*, He G*.Association study between LEPR, FTO, MC4R polymorphisms and adolescent overweight/obesity in the Chinese Han population. Gene,2019 Apr 15;692:54-59.
9. Gu Y, Wang JM, Zhang ZF,Wang J, Cao YL, Pan CJ, Yin LR, Du J(通讯作者). The Association between Polymorphisms of Genes related to Inflammation and Recurrent Pregnancy Loss. Gynecological endocrinology. 2018;34(4):349-352.
10. Xu JH, Xia L, Shang Q, Du J, Zhu DN, Wang YG,Bi D, Song J, Ma CY, Gao C, Zhang XL, Sun YY, Zhu LP, Wang XY, Zhu CL, Xing QH. A Variant of the Autophagy-Related 5 Gene is Associated with Child Cerebral Palsy. Front. Cell. Neurosci. 2017, Dec 18;11:407. doi: 10.3389/fncel.2017.00407. eCollection .
11. Liu JW, Pi L, Qian YY, Zhang ZF, Pi L, Xu JH, Du J(通讯作者). Functions of Circular RNAs in the research of reproductive and developmental medicine. Reprod Dev Med. 2017, Sep: 1 (3): 179 -183.
12. Tu X, Yu C, Gao M, Zhang Y, Zhang Z, He Y, Yao L, Du J, Sun Y, Sun Z.LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women.Per Med. 2017 Jul;14(4):299-307. doi: 10.2217/pme-2017-0016. Epub 2017 Jun 15.
13. Du J, Zhang ZF, LiWD, HeL, Xu JH, ShiYY. Association study of the TPH2 Gene with Major Depressive Disorder in the Han Chinese Population. Eur. J. Psychiat. 2016,30(2), 131-140.
14. Qian YY, Huang XL, Liang H, Zhang ZF, XuJH, ChenJP, Yuan W, He L, Wang L, Miao MH, Du J(通讯作者), Li DK.Effects of Maternal Folic Acid Supplementation on Gene Methylation and Small for Gestational Age. J Hum Nutr Diet. 2016 Oct;29(5):643-51. doi: 10.1111/jhn.12369. Epub 2016 May 27.
15. Xu JH, Zhang AP, Zhang ZF, Wang P, Qian YY, He L, Shi HJ, Xing QH, Du J(通讯作者) . DNA methylation levels of imprinted and non-imprinted genes DMRs associated with defective human sperm. Andrologia. 2016 Nov;48(9):939-947. doi: 10.1111/and.12535. [Epub ahead of print].
16. Cao YL, Zhang ZF, Wang J, Miao MH , Xu JH, Shen YP, Chen AM, Du J(通讯作者),Yuan W. Association between Polymorphisms of Prokineticin Receptor (PKR1 rs4627609 and PKR2 rs6053283) and Recurrent Pregnancy Loss. J Zhejiang Univ Sci B. 2016 Mar;17(3):218-24. doi: 10.1631/jzus.B1500180.
17. Lin Y, Chen Y, Du J, Huang X, Zhao J, Sun X. Mitochondrial D-loop Variations in Infertile Women Undergoing in Vitro Fertilization-Embryo Transfer. J Reprod Med. 2015 Sep-Oct;60(9-10):383-8.
18. Wilson RL, Buckberry S, Spronk F, Laurence JA, Leemaqz S, O'Leary S, Bianco-Miotto T, DuJ, Anderson PH, Roberts CT. Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome. PLoS One. 2015 Jun 29;10(6):e0131287. doi: 10.1371/journal.pone.0131287. eCollection 2015.
19. Huang X, Li L, Hong L, Zhou W, Shi H, Zhang H, Zhang Z, Sun X,Du J (通讯作者). The Ser680Asn Polymorphism in the Follicle-stimulating Hormone Receptor Gene is Associated with the Ovarian Response in Controlled Ovarian Hyperstimulation. Clin Endocrinol (Oxf).2015 Apr;82(4):577-83.