Yu Heguo, an associate researcher of “Molecular Andrology Research Group” (PI Researcher Shi Huijuan), Reproductive Biology Laboratory, born in Weihai of Shandong in October 1978. From 2005 to 2013, he assisted academician Zhang Yonglian in building a Joint Molecular Andrology Laboratory of Shanghai Institute of Planned Parenthood Research (SIPPR) and Institute of Biochemistry and Cell Biology, SIBS, CAS. In this period, he not only took charge of joint laboratory construction work and routine affairs, but developed sperm maturation-related epididymal function gene studies under the guidance of the academician Zhang Yonglian. Benefiting from such guidance and cultivation in multiple years, his scientific research foundations become more solid and professional literacy and skills substantially improved. As a result, he possesses an ability to select a subject independently and preside over and perform scientific research projects. From 2013 up to now, he is mainly engaged in fundamental studies on male fertility regulation mechanism and molecular mechanism of male sterility. Major research orientations are (1) relationship between effect of post-translational modification on birth control and related diseases; (2) studies on screening, druggability evaluations and mechanisms of actions of new type drugs with reproductive regulation effects; and (3) new technique and product R & D for male fertile potentiality assessment.
       He presided over multiple research subjects, including projects supported by the Natural Science Foundation of China, projects supported by Natural Science Funds of Shanghai, institutional funding projects and projects supported by SIPPR Youth Science and Technology Innovation Fund, participated in 7 subjects at national and ministerial and provincial levels as a main participant and obtained many national invention patent licenses and achievements in scientific research. Among 15 SCI papers that have been published, 7 are delivered by him as the first and the corresponding author in internationally famous academic journals such as Mol Cell Proteomics, J Biol Chem and Oncotarget, etc..
       Honors that he wins include 2013 Lianhuan Excellent Science and Technology Achievement Award; first prize of the 2015 Dahua Youth Science and Technology Innovation Award; and 2014 and 2015 Excellent Member of Communist Party in SIPPR, etc..
       Representative Papers
       1.Heguo Yu#, Hua Diao#, Chunmei Wang#, Yan Lin, Fudong Yu, Hui Lu, Wei Xu, Zheng Li, Huijuan Shi, Shimin Zhao*, Yuchuan Zhou*, and Yonglian Zhang*，Acetylproteomic Analysis Reveals Functional Implications of Lysine Acetylation in Human Spermatozoa (sperm)，Mol Cell Proteomics ,2015，14(4):1009-1023.
       2.Heguo Yu#, Jing Dong#, Yihua Gu, Haiyan Liu, Aijie Xin, Huijuan Shi, Fei Sun, Yonglian Zhang, Donghai Lin*, and Hua Diao*，The novel human beta-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss，J Biol Chem，2013，288(17):12270-12282.
       3.Haiyan Liu#, Heguo Yu#, Yihua Gu, Aijie Xin, Yonglian Zhang, Hua Diao* &Donghai Lin*，Human beta-defensin DEFB126 is capable of inhibiting LPS-mediated inflammation，Appl Microbiol Biotechnol ,2013，97(8):3395-3408.
       4.Jing Dong#, Heguo Yu#, Yonglian Zhang, Hua Diao*, Donghai Lin*，Soluble Fusion Expression and Characterization of Human Beta-defensin 3 Using a Novel Approach，Protein Pept Lett. ，2011，18, 1126-32
       5.Hua Diao#, Heguo Yu#, Fei Sun, Yong-Lian Zhang*, Nongnuj Tanphaichitr，Rat recombinant β-defensin 22 is a heparin-binding protein with antimicrobial activity，Asian J Androl，2011，13, 305-11
       6.Min Shi, Xiaojie Lu, Juan Zhang, Hua Diao, Guangming Li, Ling Xu, Ting Wang, Jue Wei, Wenying Meng,Jiali Ma, Heguo Yu*, Yugang Wang*. Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms. Oncotarget. 2016 Apr 19;7(16):22623-31. 
       7.Lianmin Bao, Hua Diao,Nian Dong, Xiaoqiong Su,Bingbin Wang, Qiongya Mo, Heguo Yu*, Xiangdong Wang*, Chengshui Chen*. Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation.Cell Biol Toxicol. 2016 Jul 16. 
       (#:Co-first author  *:Corresponding author)