Wan-xiang Xu, Professor. He graduated from the Department of Biology from Fudan University in 1975 and worked in the Department for five years. He worked in the Babraham Institute, Cambridge, UK as a Visiting Scholar from Nov 1992 to Nov 1993 after moved to Shanghai Institute of Planned Parenthood Research (SIPPR) in 1980. He has engaged in vaccine and diagnostic reagent development of human chorionic gonadotropin (hCG) and human zona pellucida. Now, his major interest is to carry out the study on B cell epitomics of interesting proteins, such as virus-encoded proteins, etc. His two major research results are: i) developing a peptide biosynthetic method used for epitope mapping using a truncated GST188 protein as carrier; and ii) decoding three linear epitomes of E6, E7 and L1 proteins of human papillomavirus type 58 using rabbits antisera to each recombinant protein, which shows the overall framework, content and meaning of the epitomics study for the first time. Up to now, he has published more than 70 articles, including many Sci papers. Also, he applied for 21 national invention patents in China, of which 14 patents has been authorized to, including 1 US patent.

        He is a member of the Council for Biological engineering Society of Shanghai and of the Expert Committee for Reproductive Immunology in Immunological Societies of Shanghai and China, and was a member of the Council for Reproductive Biology in China Zoological Society.

Recent publications (the asterisk indicates three representative papers):

1*. Xu WX, Wang J, Tang HP, He YP, Zhu QX, Gupta SK, Gu SH, Huang Q, Ji CN, Liu LF, Li GL, Xu CJ, Xie Y. Epitomics: IgG-epitome decoding of E6, E7 and L1 proteins from oncogenic human papillomavirus type 58. Sci Rep, 2016; 6: 34686; doi: 10.1038/srep34686

2. Xue F, Wang L, Liu Y, Tang HP, Xu WX, Xu C. Vaccination with an epitope peptide of IZUMO1 to induce contraception in female mice. Am J Reprod Immunol, 2016; 75: 476-485

3. Li K, Tang H, Xu W, Chen A, Shi Q, Sun Z, Wang L, Ni Y. Antisera preparation and epitope mapping of a recombinant protein comprising three peptide fragments of the cystic fibrosis transmembrane conductance regulator. Protein Expr Purif, 2015; 114: 23-29

4. Yu R, Fan X, Xu W, Li W, Dong S, Zhu Y, He YP, Tang HP, Du R, Li Z. Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus nucleoprotein. Vet Microbiol, 2015; 175: 132-138

        5.  Xu WX, Bhandari B, He YP, Tang HP, Chaudhary S, Talwar P, Gupta SK, Wang J. Mapping of epitopes relevant for induction of acrosome reaction on human zona pellucida glycoprotein-4 using monoclonal antibodies. Am J Reprod Immunol, 2012, 68(6): 465-475

        6*.  Xu WX, He YP, Wang J, Tang HP, Shi HJ, Sun XX, Ji CN, Gu SH, Xie Y. Mapping of minimal motifs of B-cell epitopes on human zona pellucida glycoprotein-3.　Clin Dev Immunol. 2012; 2012: 831010. Epub 2011 Nov 17

        7.  He YP, Xu WX (Corresponding author), Hong AZ, Liao MC, Ji CN, Gu SH, Xie Y. Immunogenic comparison for two different recombinant chimeric peptides (CP12 and CP22) containing one or two copies of three linear B cell epitopes from β-hCG subunit. J Biotech, 2011, 151(1) : 15-21

        8*.  Xu WX, He YP, Tang HP, Jia XF, Ji CN, Gu SH, Sun XX, Xie Y. Minimal motif mapping of a known epitope on human zona pellucida protein-1 using peptide biosynthesis strategy. J Reprod Immunol, 2009; 81: 9 – 16

        9*.  Wanxiang Xu, Shaohua Gu, Yaping He, Chaoneng Ji, Haiping Tang, Jian Wang, Zhida Sun and Yi Xie. Minimal motifs of linear B-cell epitopes in L1 protein from human papillomavirus type 58 and their applications. Patent No.: US 8,715,681 B2 (2014)